Adaptive Photonics Laboratory (APL) combines electro-optic engineering, real-time signal and image processing, and system integration with ultrafast laser to focus on “Advanced Nonlinear Optical Microscopy” and “Three-dimensional Photolithography.”

In regard to the advanced nonlinear optical microscopy, fast sectioning and super-resolution microscopy for thick tissue, and all-optical histology via multiphoton induced laser ablation are under developing. With respect to the three-dimensional (3D) photolithography, the design and fabrication of special 3D microstructures are developing and also for high-throughput microfabrication to match industry demand technology.

Currently, the APL has cooperation and exchanges with the research groups in the Department of Physics at National Taiwan University, Institute of Molecular Medicine at National Cheng Kung University, Department of Biomedical Engineering at U. Wisconsin-Madison, and School of Applied and Engineering Physics at Cornell U. The major research achievement is mainly produced by the state-of-art biomedical optoelectronics systems. We developed high-resolution multiphoton microscope with highest frame rate, and a high-resolution multifunctional ultrafast laser fabrication system, especially the application of fast 3D bio-imaging and microfabrication in temporal focusing based widefield multiphoton excitation microscopy, it successfully breaks the current limitations of speed and resolution in biomedical nonlinear optical microscopy.